Model Number: Nature Made® SAM-e Complete®* 400mg, 60 Tablets
"After over a year of trying a multitude of nutritional supplements (all the usual from glucosamine/chondroitin to gin-soaked raisins!) for arthritic pain in my hip, I read about SAMe and its unanticipated clinical results. It appealed to me to try something where the joint pain relief was not an intended effect of the supplement. So, I bought Costco's pack of it and followed the recommendations. On day 6, I had a surprise realization: I felt brighter, more energetic. I've never needed mood-enhancing meds, never been depressed. But it was quietly distinct. Now, almost two months after starting my daily SAMe, my hip pain is less. This varies depending on my activity level. But there's an improvement. So that I could be quasi-scientific about monitoring the effects of SAMe on my system, I stopped all other supplements except cal/mag & vit. D. The mood improvement is still noticeable in that stressful situations seem less so and the brightness continues. After a year of swallowing pills & trying all the trendy joint pain remedies, this one has multiple benefits and this happily surprised me!"
Cons: pills are large but works ok for our big dog
"Our vet recommended Sam-E for our dog instead of a prescription drug because it had fewer side effects and worked well for his other clients. We noticed a definite improvement overall in our dog within a week. In fact it worked so well and after researching the product I think I might try it myself."
"Finally, something that really DOES help my depression. I have tried about every depression med on the planet over the last 20 years, with some improvement, but still with hope to feel better after years of trying various meds. Out of desperation I tried this product, especially since it has NO side effects. I thought that if it was the highest selling prescription in Europe, perhaps it might work. It DOES work for me. I am currently taking 400 mg per day, but may increase to see if more improvements can be gained. It works on some sort of molecular binding process - I still take my prescription meds. It is SO great to find something that truly works. And with NO side effects (and I am very sensitive to meds, both OTC and prescription).. No feeling antsy, jittery, not-myself. Would give 10 stars if I could."
"I had been on anti-depressant medicine for years when Dr Amen on PBS TV advised stop the medication and use SAM-e at 400mg per day. I immediately felt a lot better, happier and life was good again. A month later I noticed that most of my gray hair was again its younger color-- a great side-effect!!! I'm 80+ and still have mostly brown hair."
Pros: takes away the tears, improves thought process, gives you the ability to be more cogent
"Due to life's challenges, I was very depressed and in tears constantly for months. A cousin (nurse) suggested I try this product so I took one per day as suggested. I researched this product on the internet before I started taking it.
After 3 weeks, didn't really feel much better (only slightly) so I increased my dose to 2 per day. After 10 days at 2/day, what a huge difference it made! The tears stopped and I can think more clearly. I am very happy I made the decision to give this a try. Also, it gave me some ambition back!
I take it every morning with my first cup of coffee because the directions say to take it on an empty stomach and no food for 1/2 hour."
"I have been using SAM-e for over 10 years. The physician who diagnosed my fibromyalgia recommended it to me, and since physicians don't usually prescribe natural supplements, I was impressed. I was more impressed with the reduction in pain levels this product achieved. The effect is cumulative, so give it at least a couple of weeks to kick in. Thank you, Dr. Gagne, and thank you, Costco!!"
"I have been using SAM-e for years, and definitely notice when I don't take it for a few days. The Nature Made carried here at Costco is absolutely the best price I've found anywhere, and I've done a LOT of looking!"
"Since I don't have insurance and have had symptoms of depression for many months, I am so glad that I tried this product. I feel much better (mentally), and it saved me from doctor bills and probably prescription meds. I started with 400 mg per day and it took about 2-1/2 weeks to feel the effects. I have not increased the dosage, but have only been taking it for about 2-1/2 months."
"This is the only thing that helps the pain in my joints...it takes a few weeks to work...doesn't happen over night...but the pain and stiffness ease up better than with the meds that my Dr. has given me. I use them both and the combo gives me great relief...knees, hip, and hands feel so much better. Can't feel any big change in my mood, but less pain makes for a happy lady."
Pros: natural, subtle, better sleep, awaken more rested
"my Rx antidepressant doesn't seem to help anymore so I tried the Sam-E. Wow!! just 1 a day for 2 weeks and already my hubby has returned to the wonderful, sweet, adorable man I married years ago!!! I'm staying with the Sam-E as long as it is available and as it is working so well to improve MY mood."
"This is a great mood stabilizing product. I have used this for a coupld of weeks and with present stomache issues I am sad to have to discontinue. The help with mood is good, but it is causing a lot of stomache discomfort. I would only be able to take this if I were to take a stomache medication that would cause malabsorbtion of all vitamins. It's a no go for me :( I am going to pass it on to my daughter in hopes she can benefit from it. Hope this helps anyone else that has a sensitive stomache."
"I have been taking SAM-e for about 6 months now. I feel better when I take it, more level headed. I am not on anti-depressants, but I've heard this is good for getting off of them. Dr. Oz recommends it for women going through menopause, as I am and it works for me! 400mg is a good dose for me too, less pills to swallow."
"I have been taking the 200 mg version for years. It is great to have the 400mg tablet now. Beats taking 2 tablets. Hard to evaluate vitamins but my blood work has been consistently great for several years. I do not know if this product helps, but I am not going to change now."
"I purchased this for my wife who has OA and in the winter suffers from SAD. This product really seemed to help her joint pain and lifted her mood. The results were not immediate, but after 2 years she has seen a real difference."
Pros: 200 mg sam-e = a perfect balance for my depression
Cons: can no longer buy 200 mg sam-e at costco!, 400 mg too strong for me! :(
"Balancing depression is very sensitive. The 400mg size Sam-e is too strong for me. I "backlash" & become very lethargic and dpressed when I take that high a dose. I cannot cut the pill in half because it then would loose its potency."
"I take a 400mg tablet every other day and now I sleep 4-6 hrs and can get back to sleep too!! I used to have to take Ativan even during the night and woke up every 2 hrs. Serotonin levels are increased with this which in turn helps increase melatonin I understand. Give it 2 weeks at least."