Cons: doesn't seem as effective over long term use
"I have been using the 400mg tablet for quite a few years now because I need knee replacement and have arthritis, and initially I thought it really helped to reduce some bone pain however I think over time your body adjusts and it becomes less effective at the 400mg dose.However, having said that I still continue to add it to my daily regimine."
"I was diagnosed with osteoarthritis of my right knee 2 years ago. The MRI shows that it is very advanced and that I have virtually no meniscus remaining in that knee, After suffering though a very painful year and getting cortisone shots to deal with the pain, based on some European studies, I asked my doctor about SAM-e. He did not think it would be helpful. I have been taking it for about a year now. I am 100% pain free and have not needed additional cortisone shots."
Cons: pills are large but works ok for our big dog
"Our vet recommended Sam-E for our dog instead of a prescription drug because it had fewer side effects and worked well for his other clients. We noticed a definite improvement overall in our dog within a week. In fact it worked so well and after researching the product I think I might try it myself."
Model Number: Nature Made® SAM-e Complete®* 400mg, 60 Tablets
"After over a year of trying a multitude of nutritional supplements (all the usual from glucosamine/chondroitin to gin-soaked raisins!) for arthritic pain in my hip, I read about SAMe and its unanticipated clinical results. It appealed to me to try something where the joint pain relief was not an intended effect of the supplement. So, I bought Costco's pack of it and followed the recommendations. On day 6, I had a surprise realization: I felt brighter, more energetic. I've never needed mood-enhancing meds, never been depressed. But it was quietly distinct. Now, almost two months after starting my daily SAMe, my hip pain is less. This varies depending on my activity level. But there's an improvement. So that I could be quasi-scientific about monitoring the effects of SAMe on my system, I stopped all other supplements except cal/mag & vit. D. The mood improvement is still noticeable in that stressful situations seem less so and the brightness continues. After a year of swallowing pills & trying all the trendy joint pain remedies, this one has multiple benefits and this happily surprised me!"
"I take a 400mg tablet every other day and now I sleep 4-6 hrs and can get back to sleep too!! I used to have to take Ativan even during the night and woke up every 2 hrs. Serotonin levels are increased with this which in turn helps increase melatonin I understand. Give it 2 weeks at least."
"I've had low back pain for years and this has seemed to make a big difference in just a week. I also have more energy. Looking forward to seeing what it's like after a month. :-) I take one in the morning and one in the afternoon with a bottle of water and no food for an hour before or after. My multi-vitamin has the B vitamins and folic acid. I haven't experienced any stomach problems or headaches."
Pros: 200 mg sam-e = a perfect balance for my depression
Cons: can no longer buy 200 mg sam-e at costco!, 400 mg too strong for me! :(
"Balancing depression is very sensitive. The 400mg size Sam-e is too strong for me. I "backlash" & become very lethargic and dpressed when I take that high a dose. I cannot cut the pill in half because it then would loose its potency."
Pros: helps aches and pains due to arthritis, easy to take
Model Number: Nature Made SAM-E Complete 400
"I have been taking SAM-E for years based on the recommendation of my doctor. It definitely works to ease aches and pains of aging and arthritis in the joints. When I run out and don't take for a few days the aches start coming back. Highly recommend."
Pros: takes away the tears, improves thought process, gives you the ability to be more cogent
"Due to life's challenges, I was very depressed and in tears constantly for months. A cousin (nurse) suggested I try this product so I took one per day as suggested. I researched this product on the internet before I started taking it.
After 3 weeks, didn't really feel much better (only slightly) so I increased my dose to 2 per day. After 10 days at 2/day, what a huge difference it made! The tears stopped and I can think more clearly. I am very happy I made the decision to give this a try. Also, it gave me some ambition back!
I take it every morning with my first cup of coffee because the directions say to take it on an empty stomach and no food for 1/2 hour."
"I started with 200MG in July 2011. Because I can only find the 400MG available and have been cutting it in half I think I will just up it to 400MG. You really don't feel different just more calm and mellow. Little things don't upset you like they use to. I take first thing in the morning on an empty stomach. To counter act any upset I take a Probiotic with 15 million which my doctor recommended. Must work because I never get an upset tummy."
"I first started taking this product to help with my postmenapausal symptoms and it works well for me with them. Then I discovered it works great for my arthritic pain. I tested it against my presecription celebrex for pain and mobility aid and I have to say for me it is a great substitute without the high risk. I have learned that I do have to take it with food on my stomache to prevent the stomache issues that can be brought on by taking medication on an empty stomache."
"A friend recommended Sam-ee to me several years ago. While the relief you feel will be subtle the effects are fantastic. I have bad knees, a wonky shoulder and lower back problems. I really believe that SAM-ee is what has saved me from having to have a knee replacement already. I get alot of relief from the pain and I'm still standing"
"This is a great mood stabilizing product. I have used this for a coupld of weeks and with present stomache issues I am sad to have to discontinue. The help with mood is good, but it is causing a lot of stomache discomfort. I would only be able to take this if I were to take a stomache medication that would cause malabsorbtion of all vitamins. It's a no go for me :( I am going to pass it on to my daughter in hopes she can benefit from it. Hope this helps anyone else that has a sensitive stomache."
"Well, I trust all the research I did in that this product with this ingredient is benefitial for my mood stability, joints and liver. But I cannot say that I feel any different. Nonetheless, I am confident it is working."
"Since I don't have insurance and have had symptoms of depression for many months, I am so glad that I tried this product. I feel much better (mentally), and it saved me from doctor bills and probably prescription meds. I started with 400 mg per day and it took about 2-1/2 weeks to feel the effects. I have not increased the dosage, but have only been taking it for about 2-1/2 months."