"I have been taking the 200 mg version for years. It is great to have the 400mg tablet now. Beats taking 2 tablets. Hard to evaluate vitamins but my blood work has been consistently great for several years. I do not know if this product helps, but I am not going to change now."
Pros: helps aches and pains due to arthritis, easy to take
Model Number: Nature Made SAM-E Complete 400
"I have been taking SAM-E for years based on the recommendation of my doctor. It definitely works to ease aches and pains of aging and arthritis in the joints. When I run out and don't take for a few days the aches start coming back. Highly recommend."
"MAKE SURE you work with your doctor however I demanded an alternative to perscription antidepressants from my doctor. She suggested SAM-e. I have had good success with SAM-e without the "stay even with no ups or downs" that you get from Rx."
Pros: 200 mg sam-e = a perfect balance for my depression
Cons: can no longer buy 200 mg sam-e at costco!, 400 mg too strong for me! :(
"Balancing depression is very sensitive. The 400mg size Sam-e is too strong for me. I "backlash" & become very lethargic and dpressed when I take that high a dose. I cannot cut the pill in half because it then would loose its potency."
"I purchased this for my wife who has OA and in the winter suffers from SAD. This product really seemed to help her joint pain and lifted her mood. The results were not immediate, but after 2 years she has seen a real difference."
"Well, I trust all the research I did in that this product with this ingredient is benefitial for my mood stability, joints and liver. But I cannot say that I feel any different. Nonetheless, I am confident it is working."
"I have been using SAM-e for years, and definitely notice when I don't take it for a few days. The Nature Made carried here at Costco is absolutely the best price I've found anywhere, and I've done a LOT of looking!"